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Isoelectric focusing of proteolytic fragments from rabbit anti‐streptococcal antibodies of restricted heterogeneity
Author(s) -
Vienne Anne,
Wikler Maurice
Publication year - 1974
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(74)80041-4
Subject(s) - microbiology and biotechnology , wright , art , philosophy , chemistry , art history , biology
It is concluded that variations in the hinge region which link Fd and Fc portions of heavy chains and differences in Fc regions, contribute to the diversity of rabbit antibodies of restricted heterogeneity which may possess identical or very similar Fab regions. Whatever the origin of the heterogeneity of the constant region of H chain may be, isoelectric spectra of papain Fab fragments of restricted antibodies reflect better than the intact molecule the 'monoclonal' nature of the combining region of antibodies and should preferentially be used as a phenotypic marker of antibody producing cells.SCOPUS: ar.jinfo:eu-repo/semantics/publishe