Premium
The microheterogeneity of human chorionic gonadotropin (HCG) reflected in the β‐subunits
Author(s) -
Graesslin D.,
Weise H.C.,
Braendle W.
Publication year - 1973
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(73)80106-1
Subject(s) - human chorionic gonadotropin , medicine , gynecology , hormone
It is now evident that human chorionic gonadotropin (hCG) is not a single molecular entity but consists of a number of different biologically active components [l-4]. By means of gel isoelectric focusing 6 hCG forms recently could be isolated and characterized [2-41. Furthermore it is well established that hCG is composed of 2 subunits: hCG-a (common to other proteohormones) and hCH-fl (hormone specific) [5,6]. The correlation, however, between the microheterogeneity of the intact hormone and the subunits was not clear. We therefore wish to present data about the interrelationship between the hCG isohormones, the subunits, and sialic acid-free hCG.