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Etude des constantes de liaison entre les oestrogenes et 1'α 1 ‐foetoproteine de rat
Author(s) -
Savu L.,
Crepy O.,
Guerin M.A.,
Nunez E.,
Engelmann F.,
Benassayag C.,
Jayle M.F.
Publication year - 1972
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(72)80233-3
Subject(s) - chemistry , microbiology and biotechnology , embryo , biology , genetics
The binding constants of the α 1 ‐foetoprotein of the rat embryo serum for oestrone and oestradiol‐17β have similar values, i.e. 1 × 10 8 M −1 in average at 25°. There is probably one binding site per mole of binding protein. The high α 1 ‐foetoprotein concentration in the rat embryo serum at 17–19 days of pregnancy explains the exceptionally high levels of fixation of the phenolsteroids by this serum.