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Enzymic synthesis of loganin by carboxyl group methylation of loganic acid
Author(s) -
Madyastha K.M.,
Guarnaccia R.,
Coscia C.J.
Publication year - 1971
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(71)80097-2
Subject(s) - st louis , chemistry , library science , medicine , computer science , art , art history
We have found that mevalonic acid-2-“C is incorporated into the aglucone moiety of the iridoid glucoside, loganic acid (fig. l), in both flowering JGzcu rosea and germinating seedlings [ I] . Loganin, its methyl ester, serves as a precursor of the nontryptophan moiety of three different classes of indole alkaloids in the same plant [2,3]. However, the occurrence of 7deoxyloganin in V. roseu has also been reported and this glucoside was found to be hydroxylated to loganin in vivb. Since tracer studies in a related species, Menyanthes tn’foliata, have revealed that the O-methyl group of loganin is derived from the methyl of methionine [4] , it was of interest to determine which monoterpene, loganic acid or 7-deoxyloganic acid, is methylated prefentially in Y rosea.