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Permeability properties of rat live endoplasmic reticulum
Author(s) -
Nilsson Robert,
Pettersson Elisabeth,
Dallner Gustav
Publication year - 1971
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(71)80085-6
Subject(s) - emergency department , university hospital , medicine , library science , family medicine , psychiatry , computer science
The semipermeability of microsomal membranes has certain important functional implications, mainly since the accessibility of a number of substrates to the membrane-bound enzymes is shown to be a limiting factor [l-3] . Changes in membrane permeability by external or internal agents may be decisive for regulating the activity of various enzymic systems [4,5] . Permeability properties also determine the size and density of the particle, which are the most important factors in the subfractionation of microsomes [6] . For the above reasons, the permeability of microsomal membranes was investigated in vitro, and experiments were performed to see whether the reaction products of one of the main microsomal enzymic systems, the hydroxylation complex, are actively transferred through the membrane during in vitro conditions.