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Effect of distamycin a on the structure and template activity of DNA in RNA — polymerase system
Author(s) -
Chandra P.,
Zimmer Ch.,
Thrum H.
Publication year - 1970
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(70)80626-3
Subject(s) - dna , rna polymerase , oligopeptide , polymerase , rna , dna polymerase , chemistry , biochemistry , rna dependent rna polymerase , dna clamp , microbiology and biotechnology , biology , reverse transcriptase , gene , peptide
It is shown that native and denatured DNA form complexes with the oligopeptide‐antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA‐polymerase system is due to the interference of the antibiotic with DNA.