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Modifications du renouvellement de l'amp final du tRNA dans le foie de rat sous l'influence de divers inhibiteurs de synthese
Author(s) -
Moulé Y.,
Landin R.M.
Publication year - 1970
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(70)80260-5
Subject(s) - chemistry , microbiology and biotechnology , biochemistry , biology
The turnover of terminal AMP of rat liver tRNA relative to that of internal AMP was studied in presence of various inhibitors. Actinomycin D and aflatoxin B 1 , which strongly depress transcription in liver, lead to an increase of the specific radioactivity of external AMP/specific radioactivity of internal AMP ratio. On the contrary, drugs which inhibit the in vivo incorporation of aminoacids determine a significant decrease of this ratio.