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Dder einfluss von liganden auf den assoziationsgrad des desoxy‐hämoglobins der flussneunaugen ( lampetra fluviatilis L.)
Author(s) -
Behlke J.,
Scheler W.
Publication year - 1970
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(70)80150-8
Subject(s) - chemistry , oligomer , monomer , aqueous solution , stereochemistry , crystallography , curtius rearrangement , polymer chemistry , polymer , organic chemistry
In alkaline aqueous solution, the sedimentation coefficients of DeoxyHb, HbO 2 and HbCO of Lampetra fluviatilis L. are 1.9 ± 0.1 S. This value corresponds to a molecular weight of about 17,000, i.e. the value of a single haem polypeptide chain. In weak acidic conditions, both the non‐liganded DeoxyHb and the liganded forms, HbO2 and HbCO, associate to form dimers and oligomers. The monomer‐oligomer transitions of these compounds take place at different pH values: DeoxyHb pHO.5 ∼ 6.7; HbO 2 and HbCO pH O.5 ∼ 5.9. With respect to the association modus, the equilibrium: 4 Hb ⇌ 2 Hb 2 ⇌Hb 4 may be preferred.