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Action du dibutyryl 3′,5′‐AMP cyclique et de l'insuline sur la synthese des acides gras dans les differentes fractions cellulaires de foie in vivo
Author(s) -
Rous S.,
Burlet M.J.,
November S.
Publication year - 1969
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(69)80114-6
Subject(s) - lipogenesis , microsome , chemistry , endocrinology , in vivo , medicine , insulin , fatty acid synthesis , hormone , metabolism , biochemistry , fatty acid , biology , in vitro , microbiology and biotechnology
3′,5′‐Cyclic AMP inhibits fatty acid synthesis in mitochondria, microsomes and supernatant but does not provoke an enrichment in 3 H with regard to 14 C as it occurs during fasting after glucose 6‐ 3 H or 6‐ 14 C administration. Insulin does not exert any action on “controls” but restores lipogenesis in fasted animals in the examinated fractions and normalises the 3 H/ 14 C ratio, even that of microsomes. Control of neoglucogenesis by this hormone is more likely than by 3′,5′‐cyclic AMP.