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Pharmacokinetics and pharmacodynamics of rocuronium at the vocal cords and the adductor pollicis in humans
Author(s) -
Plaud Benoît,
Proost Johannes H.,
Wierda J. Mark K. H.,
Barre Jérôme,
Debaene Bertrand,
Meistelman Claude
Publication year - 1995
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/0009-9236(95)90196-5
Subject(s) - adductor pollicis muscle , adductor muscles , medicine , rocuronium , pharmacodynamics , anesthesia , pharmacokinetics , neuromuscular transmission , neuromuscular blockade , thumb , anatomy , intubation , elbow , ulnar nerve
The pharmacokinetic‐pharmacodynamic relationship of rocuronium at the laryngeal adductor muscles and the adductor pollicis was determined in eight patients during general anesthesia. Rocuronium was administered as an infusion at a rate of 100 μg · kg −1 · min −1 over 5 minutes. The half‐life of transport between plasma and biophase (effect compartment) was significantly shorter at the adductor laryngeal muscles (2.7 ± 0.6 minutes, mean ± SD) than at the adductor pollicis (4.4 ± 1.5 minutes, p = 0.003). The concentration in the effect compartment producing 50% of the maximum effect was significantly greater at the adductor laryngeal muscles (1424 ± 148 μg · L −1 ) than at the adductor pollicis (823 ± 157 μg · L −1 , p = 0.0001). The shorter onset of neuromuscular blockade at the laryngeal muscles than at the adductor pollicis may be explained by a faster transfer rate at the laryngeal adductor muscles neuromuscular junction than at the adductor pollicis neuromuscular junction. Clinical Pharmacology & Therapeutics (1995) 58 , 185–191; doi: