Open AccessSensitivity enhancement in inductively coupled plasma mass spectrometry using nebulization methods via nitrogen mixed gas effect
Author(s) -
Kazuaki Yanagisawa,
Makoto Matsueda,
Makoto Furukawa,
Yoshitaka Takagai
Publication year - 2022
Publication title -
analytical sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 73
eISSN - 1348-2246
pISSN - 0910-6340
DOI - 10.1007/s44211-022-00140-4
Subject(s) - chemistry , nebulizer , inductively coupled plasma mass spectrometry , calibration curve , analytical chemistry (journal) , detection limit , mass spectrometry , nitrogen , sensitivity (control systems) , argon , inductively coupled plasma , plasma , calibration , chromatography , engineering , statistics , mathematics , medicine , physics , organic chemistry , quantum mechanics , anesthesia , electronic engineering
We demonstrate the sensitivity enhancement in inductively coupled plasma mass spectrometry (ICP-MS) by combining ultrasonic nebulization via the nitrogen mixed gas effect. We showed the effect of nitrogen gas concentration (0-5%) in the nebulizer gas on the signal sensitivity for 63 elements using commercially available (concentric and ultrasonic) nebulizers. In addition, the limit of detection (ng L -1 ) was calculated in each case. Finally, we compared the sensitivity (i.e., the slope of the calibration curve), background noise intensity, and three-dimensional intensity distribution in the plasma to elucidate the effects of the concurrent use of mixed gas plasmas and nebulization methods.