Open AccessSelective detection of HSO3− in living cells using a pyrroloquinoline structure containing turn-on fluorescent probe
Author(s) -
Jiahua Zhou,
Fa Wang,
Yuan-Xiang Xu,
Xiaosong Gu,
Yujun Shi,
Bing Yang
Publication year - 2022
Publication title -
analytical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 73
eISSN - 1348-2246
pISSN - 0910-6340
DOI - 10.1007/s44211-022-00126-2
Subject(s) - chemistry , detection limit , fluorescence , turn (biochemistry) , molecular probe , linear range , stereochemistry , chromatography , biochemistry , optics , physics , dna
A turn-on fluorescence probe PQP-1 with a pyrroloquinoline skeleton has been designed and synthesized. Probe PQP-1 showed high sensitivity to HSO 3 - , low detection limit (16.83 nM), and a wide linear range (50-3000 μM). More importantly, probe PQP-1 could distinguish between HSO 3 - and SO 3 2- . Furthermore, cell imaging experiments of HSO 3 - in HeLa cells revealed that probe PQP-1 had potential application value in biological systems.