Open AccessMesenchymal Stem Cell Therapy in Chondral Defects of Knee: Current Concept Review
Author(s) -
Ujjwal K. Debnath
Publication year - 2020
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.1007/s43465-020-00198-0
Subject(s) - medicine , osteoarthritis , mesenchymal stem cell , chondrogenesis , cartilage , fibrocartilage , cochrane library , regeneration (biology) , articular cartilage repair , bioinformatics , pathology , articular cartilage , anatomy , randomized controlled trial , biology , alternative medicine , microbiology and biotechnology
Full-thickness cartilage defects if left alone would increase the risk of osteoarthritis (OA) with severe associated pain and functional disability. Articular cartilage defect may result from direct trauma or chronic degeneration. The capability of the mesenchymal stem cells (MSCs) to repair and regenerate cartilage has been widely investigated. This review describes current trends in MSC biology, the sourcing, expansion, application and role of MSCs in chondral defects of human knees.