Open AccessCOLIA1 + 1245 G > T Sp1 Binding Site Polymorphism is Not Associated with ACL Injury Risks Among Indian Athletes
Author(s) -
Manish Shukla,
Rahul Gupta,
Vivek Pandey,
Pramod Kumar Tiwari,
Rabbind Singh Amrathlal
Publication year - 2020
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.1007/s43465-020-00119-1
Subject(s) - medicine , anterior cruciate ligament , genotype , allele , single nucleotide polymorphism , tears , genetics , gene , biology , surgery
Type I collagen polypeptides contribute significantly to the structural composition of ligament tissue matrix. Since anterior cruciate ligament (ACL) tears account for roughly 50% of all knee injuries in sports, the objective of the study was to investigate association of Sp1-transcription factor binding site polymorphism COLIA1 Sp1 + 1245 G > T with ACL injury risk among Indian athletes.