In vitro activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2 against clinically important bacteria | Zendy

Laura Bedin Denardi | Zendy; Priscila de Arruda Trindade | Zendy; Carla Weiblen | Zendy; Lara Baccarin Ianiski | Zendy; Paula Cristina Stibbe | Zendy; Stefania Campos Pinto | Zendy; Jânio Morais Santúrio | Zendy

Open Access

In vitro activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2 against clinically important bacteria

Author(s) -

Laura Bedin Denardi,

Priscila de Arruda Trindade,

Carla Weiblen,

Lara Baccarin Ianiski,

Paula Cristina Stibbe,

Stefania Campos Pinto,

Jânio Morais Santúrio

Publication year - 2021

Publication title -

brazilian journal of microbiology

Language(s) - English

Resource type - Journals

eISSN - 1678-4405

pISSN - 1517-8382

DOI - 10.1007/s42770-021-00645-6

Subject(s) - magainin , microbiology and biotechnology , antimicrobial , acinetobacter baumannii , broth microdilution , antibacterial activity , staphylococcus aureus , pseudomonas aeruginosa , minimum inhibitory concentration , klebsiella pneumoniae , chemistry , bacteria , escherichia coli , antimicrobial peptides , biology , biochemistry , genetics , gene

We investigated the antibacterial activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2. The minimum inhibitory concentration (MIC) was determined by microdilution technique according to CLSI (M07-A9, 2012) against Escherichia coli, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, carbapenem-resistant Klebsiella pneumoniae, and Acinetobacter baumannii. The MSI-78 showed potent bactericidal activity with MIC range of 1.25-40 mg/L against all bacterial strains. The h-Lf1-11, magainin-2, and LL-37 exhibited moderate activity (MIC range of 40-160, 80-160, and 40-160 mg/L, respectively) while the fengycin 2B did not show significant activity against all bacterial strains tested. These results revealed that MSI-78, h-Lf1-11, magainin-2, and LL-37 have great potential as antibacterial agents and their activity deserves to be more explored in further studies for the treatment of antibiotic-resistant bacteria.

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