Open AccessRepurposing of antidiabetics as Serratia marcescens virulence inhibitors
Author(s) -
Wael A. H. Hegazy,
Maan T. Khayat,
Tarek S. Ibrahim,
Mаhmoud Youns,
Rasha Mosbah,
Wafaa E. Soliman
Publication year - 2021
Publication title -
brazilian journal of microbiology
Language(s) - English
Resource type - Journals
eISSN - 1678-4405
pISSN - 1517-8382
DOI - 10.1007/s42770-021-00465-8
Subject(s) - serratia marcescens , repurposing , virulence , microbiology and biotechnology , medicine , biology , escherichia coli , biochemistry , ecology , gene
Serratia marcescens becomes an apparent nosocomial pathogen and causes a variety of infections. S. marcescens possess various virulence factors that are regulated by intercellular communication system quorum sensing (QS). Targeting bacterial virulence is a proposed strategy to overcome bacterial resistance. Sitagliptin anti-QS activity has been demonstrated previously and we aimed in this study to investigate the effects of antidiabetic drugs vildagliptin and metformin compared to sitagliptin on S. marcescens pathogenesis.