Open AccessBioreactor design and validation for manufacturing strategies in tissue engineering
Author(s) -
Diana Lim,
Eric S. Renteria,
Drake S. Sime,
Young Min Ju,
Ji Hyun Kim,
Tracy Criswell,
Thomas Shupe,
Anthony Atala,
Frank C. Marini,
Metin N. Gürcan,
Shay Söker,
Joshua Hunsberger,
Jennie Yoo
Publication year - 2021
Publication title -
bio-design and manufacturing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.758
H-Index - 11
eISSN - 2522-8552
pISSN - 2096-5524
DOI - 10.1007/s42242-021-00154-3
Subject(s) - bioreactor , tissue engineering , quality assurance , biochemical engineering , regenerative medicine , scaffold , automation , function (biology) , biomedical engineering , computer science , manufacturing engineering , process engineering , engineering , mechanical engineering , chemistry , stem cell , biology , operations management , external quality assessment , organic chemistry , evolutionary biology , genetics
The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore, maintain or improve tissue function following disease or injury. To maximize the biological function of a tissue-engineered clinical product, specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for implantation. Specifically, the bioreactor should be designed to mimic the mechanical, electrochemical and biochemical environment that the product will be exposed to in vivo. Real-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management process. The present review provides a brief overview of bioreactor engineering considerations. In addition, strategies for bioreactor automation, in-line product monitoring and quality assurance are discussed.