Open AccessBioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces
Author(s) -
Mohammed Barajaa,
Lakshmi S. Nair,
Cato T. Laurencin
Publication year - 2019
Publication title -
regenerative engineering and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 11
eISSN - 2364-4133
pISSN - 2364-4141
DOI - 10.1007/s40883-019-00132-3
Subject(s) - scaffold , regeneration (biology) , interface (matter) , mechanism (biology) , computer science , tissue engineering , regenerative medicine , function (biology) , orthopedic surgery , biomedical engineering , engineering , biology , medicine , microbiology and biotechnology , stem cell , physics , surgery , bubble , quantum mechanics , maximum bubble pressure method , parallel computing
The musculoskeletal system works at a very advanced level of synchrony, where all the physiological movements of the body are systematically performed through well-organized actions of bone in conjunction with all the other musculoskeletal soft tissues, such as ligaments, tendons, muscles, and cartilage through tissue-tissue interfaces. Interfaces are structurally and compositionally complex, consisting of gradients of extracellular matrix components, cell phenotypes as well as biochemical compositions and are important in mediating load transfer between the distinct orthopedic tissues during body movement. When an injury occurs at interface, it must be re-established to restore its function and stability. Due to the structural and compositional complexity found in interfaces, it is anticipated that they presuppose a concomitant increase in the complexity of the associated regenerative engineering approaches and scaffold designs to achieve successful interface regeneration and seamless integration of the engineered orthopedic tissues. Herein, we discuss the various bioinspired scaffold designs utilized to regenerate orthopedic tissue interfaces. First, we start with discussing the structure-function relationship at the interface. We then discuss the current understanding of the mechanism underlying interface regeneration, followed by discussing the current treatment available in the clinic to treat interface injuries. Lastly, we comprehensively discuss the state-of-the-art scaffold designs utilized to regenerate orthopedic tissue interfaces.