Open AccessIntegration of Mechanical and ECM Microenvironment Signals in the Determination of Cancer Stem Cell States
Author(s) -
Tiina Jokela,
Mark A. LaBarge
Publication year - 2020
Publication title -
current stem cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 17
ISSN - 2198-7866
DOI - 10.1007/s40778-020-00182-2
Subject(s) - tumor microenvironment , cancer stem cell , integrin , context (archaeology) , microbiology and biotechnology , signal transduction , cancer cell , biology , stem cell , extracellular matrix , tumor progression , cell signaling , cancer research , cancer , cell , chemistry , tumor cells , genetics , paleontology
Cancer stem cells (CSCs) are increasingly understood to play a central role in tumor progression. Growing evidence implicates tumor microenvironments as a source of signals that regulate or even impose CSC states on tumor cells. This review explores points of integration for microenvironment-derived signals that are thought to regulate CSCs in carcinomas.