Open AccessStem Cell Metabolism and Diet
Author(s) -
Marine Barthez,
Zehan Song,
Chih Ling Wang,
Danica Chen
Publication year - 2020
Publication title -
current stem cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 17
ISSN - 2198-7866
DOI - 10.1007/s40778-020-00180-4
Subject(s) - stem cell , biology , nutrient sensing , microbiology and biotechnology , hematopoietic stem cell , haematopoiesis , signal transduction
Diet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we review the similarities and differences in the metabolism of stem cells from several tissues, and highlight the mitochondrial metabolic checkpoint in stem cell maintenance and aging. We discuss how diet engages the nutrient sensing metabolic pathways and impacts stem cell maintenance. Finally, we explore the therapeutic implications of dietary and metabolic regulation of stem cells.