Open AccessMechanistic Insights into Factor VIII Immune Tolerance Induction via Prenatal Cell Therapy in Hemophilia A
Author(s) -
Martin Rodriguez,
Christopher D. Porada,
Graça Almeida-Porada
Publication year - 2019
Publication title -
current stem cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 17
ISSN - 2198-7866
DOI - 10.1007/s40778-019-00165-y
Subject(s) - context (archaeology) , genetic enhancement , immunology , immune tolerance , prenatal diagnosis , immune system , medicine , antigen , cell therapy , t cell , cell , fetus , biology , gene , pregnancy , genetics , paleontology
Prenatal stem cell and gene therapy approaches are amongst the few therapies that can promise the birth of a healthy infant with specific known genetic diseases. This review describes fetal immune cell signaling and its potential influence on donor cell engraftment, and summarizes mechanisms of central T cell tolerance to peripherally-acquired antigen in the context of prenatal therapies for Hemophilia A.