Open AccessPrimary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro
Author(s) -
Xiaofei Ma,
Chengxu Ma,
Wengui Shi,
Jian Zhou,
Huiping Ma,
Yuhai Gao,
Cory J. Xian,
K.-M. Chen
Publication year - 2016
Publication title -
journal of endocrinological investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.034
H-Index - 84
eISSN - 1720-8386
pISSN - 0391-4097
DOI - 10.1007/s40618-016-0568-8
Subject(s) - mineralization (soil science) , cilium , in vitro , chemistry , microbiology and biotechnology , biology , biochemistry , organic chemistry , nitrogen
Icaritin, one effective metabolite of Herba Epimedii-derived flavonoid icariin, has a strong osteogenic activity. However, its action mechanism remains unclear. Since primary cilia have been shown to play a pivotal role in regulating the osteogenesis, we hypothesized primary cilia are indispensable in mediating icaritin osteogenic effect.
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