Open AccessListeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity
Author(s) -
Zachary Morrow,
Zachary M. Powers,
John-Demian Sauer
Publication year - 2019
Publication title -
current clinical microbiology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.657
H-Index - 16
ISSN - 2196-5471
DOI - 10.1007/s40588-019-00133-4
Subject(s) - immune system , innate immune system , listeria monocytogenes , acquired immune system , immunology , biology , immunity , immunotherapy , priming (agriculture) , cancer immunotherapy , cancer , t cell , bacteria , genetics , germination , botany
Immunotherapy has emerged as a promising cancer treatment, however success in only select clinical indications underscores the need for novel approaches. Recently Listeria monocytogenes- based vaccines have been developed to drive tumor specific T-cell responses. Here, we discuss recent preclinical studies using L. monocytogenes vaccines, innate immune pathways that influence T-cell priming, and new vaccine strategies in clinical trials.