Open AccessMinimally Invasive Biospecimen Collection for Exposome Research in Children’s Health
Author(s) -
Lauren Petrick,
Manish Arora,
Megan M. Niedzwiecki
Publication year - 2020
Publication title -
current environmental health reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 39
ISSN - 2196-5412
DOI - 10.1007/s40572-020-00277-2
Subject(s) - exposome , biorepository , medicine , biomarker , metabolomics , data science , biobank , environmental health , bioinformatics , computer science , biology , biochemistry
The advent of low-volume biosampling and novel biomarker matrices offers non- or minimally invasive approaches to sampling in children. These new technologies, combined with advancements in mass spectrometry that provide high sensitivity, robust measurements of low-concentration exposures, facilitate the application of untargeted metabolomics in children's exposome research. Here, we review emerging sampling technologies for alternative biomatrices-dried capillary blood, interstitial fluid, saliva, teeth, and hair-and highlight recent applications of these samplers to drive discovery in population-based exposure research.