Open AccessFilaggrin Gene Mutations with Special Reference to Atopic Dermatitis
Author(s) -
Jayanta Gupta,
David J. Margolis
Publication year - 2020
Publication title -
current treatment options in allergy
Language(s) - English
Resource type - Journals
ISSN - 2196-3053
DOI - 10.1007/s40521-020-00271-x
Subject(s) - filaggrin , atopic dermatitis , dermatology , genetic association , genetics , medicine , genome wide association study , ichthyosis vulgaris , gene , biology , genotype , single nucleotide polymorphism
Mutations in the Filaggrin gene can cause absent or reduced filaggrin protein, leading to impaired keratinization and skin barrier defect, which produce characteristic phenotypes. In this short review, we report current evidence on the topic with special reference to atopic dermatitis, suggest future directions, and discuss therapeutic implications.