Open AccessMeasuring Within-Individual Cannabis Reduction in Clinical Trials: a Review of the Methodological Challenges
Author(s) -
Rachel L. Tomko,
Kevin M. Gray,
Marilyn A. Huestis,
Lindsay M. Squeglia,
Nathaniel L. Baker,
Erin A. McClure
Publication year - 2019
Publication title -
current addiction reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 26
ISSN - 2196-2952
DOI - 10.1007/s40429-019-00290-y
Subject(s) - cannabis , abstinence , effects of cannabis , psychiatry , clinical trial , psychology , cannabis dependence , clinical psychology , medicine , cannabidiol
Cannabis abstinence traditionally is the primary outcome in cannabis use disorder (CUD) treatment trials. Due to the changing legality of cannabis, patient goals, and preliminary evidence that suggests individuals who reduce their cannabis use may show functional improvements, cannabis reduction is a desirable alternative outcome in CUD trials. We review challenges in measuring cannabis reduction and the evidence to support various definitions of reduction.