Open AccessPhysiologically Based Pharmacokinetic Modeling Framework to Predict Neonatal Pharmacokinetics of Transplacentally Acquired Emtricitabine, Dolutegravir, and Raltegravir
Author(s) -
Xiaomei I. Liu,
Jeremiah D. Momper,
Natella Rakhmanina,
Dionna J. Green,
Gilbert J. Burckart,
Tim R. Cressey,
Mark Mirochnick,
Brookie M. Best,
John N. van den Anker,
André Dallmann
Publication year - 2021
Publication title -
clinical pharmacokinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.549
H-Index - 164
eISSN - 1179-1926
pISSN - 0312-5963
DOI - 10.1007/s40262-020-00977-w
Subject(s) - dolutegravir , pharmacokinetics , raltegravir , emtricitabine , medicine , physiologically based pharmacokinetic modelling , pharmacology , drug , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , family medicine
Little is understood about neonatal pharmacokinetics immediately after delivery and during the first days of life following intrauterine exposure to maternal medications. Our objective was to develop and evaluate a novel, physiologically based pharmacokinetic modeling workflow for predicting perinatal and postnatal disposition of commonly used antiretroviral drugs administered prenatally to pregnant women living with human immunodeficiency virus.