Population Pharmacokinetics of Unbound and Total Teicoplanin in Critically Ill Pediatric Patients | Zendy

Linda B. S. Aulin | Zendy; Peter De Paepe | Zendy; Evelyn Dhont | Zendy; Annick De Jaeger | Zendy; Johan Vande Walle | Zendy; Wim Vandenberghe | Zendy; Brett McWhinney | Zendy; Jacobus Ungerer | Zendy; J. G. Coen van Hasselt | Zendy; Pieter De Cock | Zendy

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Population Pharmacokinetics of Unbound and Total Teicoplanin in Critically Ill Pediatric Patients

Author(s) -

Linda B. S. Aulin,

Peter De Paepe,

Evelyn Dhont,

Annick De Jaeger,

Johan Vande Walle,

Wim Vandenberghe,

Brett McWhinney,

Jacobus Ungerer,

J. G. Coen van Hasselt,

Pieter De Cock

Publication year - 2020

Publication title -

clinical pharmacokinetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.549

H-Index - 164

eISSN - 1179-1926

pISSN - 0312-5963

DOI - 10.1007/s40262-020-00945-4

Subject(s) - pharmacokinetics , teicoplanin , dosing , medicine , population , pharmacology , pharmacodynamics , therapeutic drug monitoring , renal function , intensive care medicine , vancomycin , biology , environmental health , bacteria , genetics , staphylococcus aureus

Teicoplanin is a highly protein-bound antibiotic, increasingly used to treat serious Gram-positive infections in critically ill children. Maturational and pathophysiological intensive care unit-related changes often lead to altered pharmacokinetics. In this study, the objectives were to develop a pediatric population-pharmacokinetic model of unbound and total teicoplanin concentrations, to investigate the impact of plasma albumin levels and renal function on teicoplanin pharmacokinetics, and to evaluate the efficacy of the current weight-based dosing regimen.

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