Open AccessA Population Pharmacokinetic Analysis of PF-5190457, a Novel Ghrelin Receptor Inverse Agonist in Healthy Volunteers and in Heavy Alcohol Drinkers
Author(s) -
Enoch Cobbina,
Mary R. Lee,
Lorenzo Leggio,
Fatemeh Akhlaghi
Publication year - 2020
Publication title -
clinical pharmacokinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.549
H-Index - 164
eISSN - 1179-1926
pISSN - 0312-5963
DOI - 10.1007/s40262-020-00942-7
Subject(s) - pharmacokinetics , volume of distribution , population , nonmem , pharmacology , medicine , chemistry , environmental health
The ghrelin receptor (GHS-R1a) is a potential target for alcohol use disorders. PF-5190457 is the first inverse agonist of GHS-R1a to progress to clinical development with potential to treat alcohol use disorder. We present a population pharmacokinetic model for PF-5190457 in non-heavy (alcohol consumption status = 0) and heavy alcohol drinkers (alcohol consumption status = 1), and identify relevant factors that can influence its pharmacokinetics.