Open AccessOptimizing Estimated Glomerular Filtration Rate to Support Adult to Pediatric Pharmacokinetic Bridging Studies in Patients with Cystic Fibrosis
Author(s) -
Ryan L. Crass,
Manjunath P. Pai
Publication year - 2019
Publication title -
clinical pharmacokinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.549
H-Index - 164
eISSN - 1179-1926
pISSN - 0312-5963
DOI - 10.1007/s40262-019-00761-5
Subject(s) - medicine , renal function , pharmacokinetics , cystic fibrosis , bridging (networking) , pharmacotherapy , intensive care medicine , urology , metabolic clearance rate , pharmacology , computer science , computer network
The estimated glomerular filtration rate (eGFR) is often used to model drug clearance (CL) and scale doses across age and body size. Over their lifetime, patients with cystic fibrosis (CF) receive repeated courses of tobramycin, an antibiotic with eGFR-dependent CL, for the treatment of pulmonary exacerbations. Tobramycin population pharmacokinetic (PK) modeling can be used to decipher the best approach to define eGFR for pediatric bridging studies.