Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John’s Wort | Zendy

Jeffry Adiwidjaja | Zendy; Alan V. Boddy | Zendy; Andrew J. McLachlan | Zendy

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Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John’s Wort

Author(s) -

Jeffry Adiwidjaja,

Alan V. Boddy,

Andrew J. McLachlan

Publication year - 2019

Publication title -

clinical pharmacokinetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.549

H-Index - 164

eISSN - 1179-1926

pISSN - 0312-5963

DOI - 10.1007/s40262-019-00736-6

Subject(s) - hyperforin , pharmacokinetics , hypericum perforatum , drug , pharmacology , chemistry , medicine

Herb-drug interactions with St John's wort (SJW) have been widely studied in numerous clinical studies. The objective of this study was to develop and evaluate a physiologically based pharmacokinetic (PBPK) model for hyperforin (the constituent of SJW responsible for interactions), which has the potential to provide unique insights into SJW interactions and allow prediction of the likely extent of interactions with SJW compared to published interaction reports.

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