Open AccessNigella/honey/garlic/olive oil co-loaded PVA electrospun nanofibers for potential biomedical applications
Author(s) -
Md Nur Uddin,
Md. Mohebbullah,
Syed Maminul Islam,
Mohammad Nazim Uddin,
Md. Jobaer
Publication year - 2022
Publication title -
progress in biomaterials
Language(s) - English
Resource type - Journals
eISSN - 2194-0509
pISSN - 2194-0517
DOI - 10.1007/s40204-022-00207-5
Subject(s) - electrospinning , nanofiber , polyvinyl alcohol , materials science , fourier transform infrared spectroscopy , absorbance , antibacterial activity , nigella sativa , thermal stability , solvent , nuclear chemistry , chemical engineering , chemistry , polymer , composite material , organic chemistry , chromatography , traditional medicine , bacteria , medicine , biology , engineering , genetics
The current work focuses on the formation of nanofibrous mats without the use of toxic solvents and metallic nanoparticles utilizing polyvinyl alcohol (PVA) and a blend of nigella, honey, garlic, and olive oil. Using deionized water (DI) water as a solvent, nanofibrous mats composed of PVA/nigella/honey (PNH) and PVA/garlic/honey/olive oil (PGHO) were developed. Methanol extraction was utilized to extract the therapeutic components of nigella sativa. Antibacterial and moisture management tests (MMT) were employed to examine the antibacterial and absorbance characteristics of the PNH and PGHO nanofibrous. Scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR) tests were employed to analyze the morphological and chemical characteristics. PGHO showed thermal stability up to 245 °C, and PNH withstands until 225 °C. PNH and PGHO both exhibited antibacterial activity against Staphylococcus aureus (S. aureus), with inhibition zones of 36 mm and 35 mm, respectively. The synthesized materials exhibited excellent absorbance properties, thermal stability, cytotoxicity, and the production of thin nanofibers with an average diameter between 150 and 170 nm. The samples were characterized using FTIR spectra, which confirmed the presence of all components in the developed samples. To date, extensive research on electrospinning for biomedical applications has been undertaken using a variety of hazardous solvents and metallic nanoparticles. Briefly, our objective is to develop nanofibrous materials from plant extracts through a process called "green electrospinning" to observe the synergistic effect of multiple biocomponents incorporated nanofibers avoiding toxic solvents and metallic compounds for potential biomedical applications.