Open AccessFast-dissolving oral films containing dextromethorphan/phenylephrine for sinusitis treatment: formulation, characterization and optimization
Author(s) -
Mozhgan Moonesan,
Fariba Ganji,
Arezoo Soroushnia,
Fatemeh Bagheri
Publication year - 2022
Publication title -
progress in biomaterials
Language(s) - English
Resource type - Journals
eISSN - 2194-0509
pISSN - 2194-0517
DOI - 10.1007/s40204-022-00191-w
Subject(s) - plasticizer , microcrystalline cellulose , materials science , dissolution , folding endurance , polyethylene glycol , ultimate tensile strength , composite material , polymer , chemical engineering , cellulose , casting , ethyl cellulose , engineering
This work uses optimization study to formulate a patient-friendly antitussive fast-dissolving oral film based on phenylephrine hydrochloride (Phen) and dextromethorphan hydrobromide (Dex). The designed films were based on hydroxypropylmethyl cellulose (HPMC) with two grades (E5 and E50) as a film-forming polymer by the solvent-casting method. Polyethylene glycol with two molar masses (400 and 1000) was used as a plasticizer, while aspartame was used as a sweetener and microcrystalline cellulose intended to act as a disintegrant. To find an optimum formulation, a response surface methodology and a central composite design were employed. The percentage of HPMC E50, and PEG, as a plasticizer, were considered to be the design factors. Film thickness, surface pH, disintegration time, dissolution percent, tensile strength, elongation percent and folding endurance were considered to be the responses. A film with 11.46% E50, 88.54% E5, 25% of two drugs (8.4% of Phen and 16.6% of Dex) and 18.54% plasticizer is designed and prepared as the optimum formulation for Phen/Dex fast-dissolving oral films, with 95% confidence levels.