Open AccessA systematic review of miRNAs as biomarkers in osteoporosis disease
Author(s) -
Mandana Hasanzad,
Maryam Hassani Doabsari,
Marzieh Rahbaran,
Pantea Banihashemi,
Fatemeh Fazeli,
Mehrnoush Ganji,
Shahrzad Manavi Nameghi,
Negar Sarhangi,
Shekoufeh Nikfar,
Hamid Reza Aghaei Meybodi
Publication year - 2021
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-021-00873-5
Subject(s) - disease , osteoporosis , microrna , medicine , bioinformatics , computational biology , biology , pathology , genetics , gene
Osteoporosis is often considered to be a disease of the elderly, which is characterized by two characteristics: low bone mineral density (BMD) and increased risk of fracture. MicroRNAs (miRNAs) have been reported to play a potential role in bone formation and resorption, bone remodeling, bone homeostasis regulation, and bone cell differentiation. Therefore, altered expression of different miRNAs may impact the pathology of bone diseases such as osteoporosis. A systematic review was conducted to extract all miRNA found to be significantly dys-regulated in the peripheral blood.