Open AccessThe role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk
Author(s) -
Leila Hashemian,
Negar Sarhangi,
Mahdi Afshari,
Hamid Reza Aghaei Meybodi,
Mandana Hasanzad
Publication year - 2021
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-021-00872-6
Subject(s) - peroxisome proliferator activated receptor gamma , medicine , genotyping , type 2 diabetes , type 2 diabetes mellitus , insulin resistance , allele , endocrinology , sanger sequencing , allele frequency , population , diabetes mellitus , genotype , genetics , biology , peroxisome proliferator activated receptor , gene , mutation , receptor , environmental health
Type 2 diabetes (T2DM) prevalence has been rapidly increasing in the last decades. T2DM pathogenesis is related to insulin resistance and beta-cell dysfunction. Peroxisome proliferator-activated receptor gamma (PPARG) is concerned about T2DM risk through the involvement in adipocyte differentiation and energy homeostasis. The present study aimed to find the risk associated with a common genetic variant (Pro12Ala) of the PPARG gene in the development of T2DM in a group of the Iranian population.