Open AccessVitamin D3 attenuates oxidative stress and regulates glucose level and leukocyte count in a semi-chronic streptozotocin-induced diabetes model
Author(s) -
Maja MitrašinovićBrulić,
Amela Dervišević,
Asija Začiragić,
Muhamed Fočak,
Amina Valjevac,
Almira Hadžović-Dzuvo,
Damir Suljević
Publication year - 2021
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-021-00814-2
Subject(s) - streptozotocin , medicine , endocrinology , malondialdehyde , vitamin , eosinophil , diabetes mellitus , oxidative stress , monocyte , immune system , baicalein , chemistry , pharmacology , immunology , asthma
Vitamin D3 (vit-D3) is a potent immunomodulator with anti-inflammatory and antioxidative properties. We used streptozotocin (STZ)-induced rat model of diabetes (DM) to evaluate the effects of vit-D3. We measured serum biochemical parameters, interleukin-17 (IL-17), osteocalcin (OC), malondialdehyde (MDA), and immune cell count on the 21st day of experiment.