Open AccessAssociation study between superoxide Dismutases gene polymorphisms and development of diabetic retinopathy and cataract in Iranian patients with type two diabetes mellitus
Author(s) -
Leila Saremi,
Somayye Taghvaei,
Fatemeh Feizy,
Mohammad Ebrahim Ghaffari,
Sepideh Babaniamansour,
Zohreh Saltanatpour
Publication year - 2021
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-021-00790-7
Subject(s) - medicine , diabetes mellitus , diabetic retinopathy , genotype , genotyping , superoxide dismutase , type 2 diabetes , type 2 diabetes mellitus , gastroenterology , sod1 , ophthalmology , gene , oxidative stress , endocrinology , genetics , biology
Reactive oxygen species (ROS) plays pathological roles on development of diabetic retinopathy (DR) and cataract. Superoxide dismutases (SODs) are a set of enzymes to eliminate ROS and cell protection. Based on the diminished activities of SOD1 during DR and cataract, the polymorphisms within SOD1 gene may be associated with these disorders. This study assessed the relationship between SOD1 -251A/G (rs2070424) and SOD1 + 35A/C (rs2234694) gene polymorphisms and DR and cataract in Iranian patients with type 2 diabetes mellitus (T2DM).