Open AccessMomordica charantia silver nanoparticles modulate SOCS/JAK/STAT and P13K/Akt/PTEN signalling pathways in the kidney of streptozotocin-induced diabetic rats
Author(s) -
Olusola Olalekan Elekofehinti,
Victor Oluwatoyin Oyedokun,
Opeyemi Iwaloye,
Akeem O. Lawal,
Oluwamodupe Cecilia Ejelonu
Publication year - 2021
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-021-00739-w
Subject(s) - momordica , streptozotocin , pi3k/akt/mtor pathway , diabetic nephropathy , pten , protein kinase b , pharmacology , endocrinology , metformin , diabetes mellitus , medicine , chemistry , signal transduction , biochemistry , traditional medicine
Diabetes nephropathy (DN) is one of the complications of diabetes mellitus (DM) marked by gradual progressive loss of renal function. SOCS/JAK/STAT and PI3K/Akt/PTEN signalling pathways are among the chain of interactions implicated in the onset, progression and pathology of DN. Momordica charantia (bitter melon) is often used in folk medicine as therapy for DM due to its hypoglycemic properties. This study was designed to evaluate M. charantia silver nanoparticles' therapeutic effect on DN-induced by streptozotocin (STZ) in Wistar rats.