Open AccessFour weeks exercise training enhanced the hepatic insulin sensitivity in high fat- and high carbohydrate-diet fed hyperinsulinemic rats
Author(s) -
Abin John Joseph,
Subramanian S. Parvathy,
Koyikkal Karthikeya Varma,
Aiswarya Nandakumar
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00694-y
Subject(s) - medicine , endocrinology , hyperinsulinemia , insulin receptor , insulin , irs1 , glucose transporter , oxidative stress , glucose homeostasis , insulin resistance , carbohydrate metabolism , diabetes mellitus
Hyperinsulinemia is considered the primary defect underlying the development of type 2 diabetes. The liver is essential for the regular glucose homeostasis. In this study, we examined the effect of physical training on the insulin signaling, oxidative stress enzymes and Glucose-6-phosphatase(G6Pase) activity in the liver of Wistar rats.