Open AccessConcurrent metformin and silibinin therapy in diabetes: assessments in zebrafish (Danio rerio) animal model
Author(s) -
Hassan Reza Mohammadi,
Hamed Manouchehri,
Reza Changizi,
Fatemeh Bootorabi,
Mohammad Reza Khorramizadeh
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00637-7
Subject(s) - metformin , silibinin , diabetes mellitus , medicine , endocrinology , h&e stain , danio , zebrafish , pharmacology , biology , gene , immunohistochemistry , biochemistry
In this study, zebrafish was used as a biological model to induce type 2 diabetes mellitus through glucose. Then, the effect of metformin and silibinin combination was examined on elevated blood glucose, intestinal tissues, liver enzymes, and TNF-α, IFN-γ, INL1β genes as inflammation marker genes.