Open AccessPreserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
Author(s) -
Tomislav Bulum,
Martina Tomić,
Sandra Vučković-Rebrina,
Vinko Roso,
Marijana Vučić Lovrenčić,
Lea Duvnjak
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00620-2
Subject(s) - medicine , uric acid , resistin , c peptide , type 1 diabetes , endocrinology , diabetes mellitus , incidence (geometry) , type 2 diabetes , gastroenterology , insulin resistance , physics , optics , adipokine
Previous studies suggested that long-term perseverance of beta-cell function in patients with type 1 diabetes (T1DM) is associated with lower incidence of microvascular complications. The objective of this study was to evaluate preserved C-peptide secretion in patients with T1DM without overt chronic complications and to explore associations with resistin and uric acid as biomarkers of microvascular complication pathogenesis.