Open AccessLow advanced Glycation end product diet improves the central obesity, insulin resistance and inflammatory profiles in Iranian patients with metabolic syndrome: a randomized clinical trial
Author(s) -
Razieh Goudarzi,
Meghdad Sedaghat,
Mehdi Hedayati,
Azita Hekmatdoost,
Golbon Sohrab
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00614-0
Subject(s) - medicine , insulin resistance , glycemic , overweight , obesity , metabolic syndrome , malondialdehyde , lipid profile , endocrinology , randomized controlled trial , insulin , calorie restriction , anthropometry , oxidative stress , gastroenterology , cholesterol
The study aimed to investigate the effects of 8-weeks AGEs restricted diet on glycemic control as well as lipid profile, inflammatory and oxidative stress biomarkers and IR in overweight patients with Mets. In this randomized, controlled clinical trial 40 clients were randomly assigned to take either a low AGE (L-AGE) or a regular AGE (Reg-AGE) diet. Also, both groups were advised to follow an energy-restricted diet. At baseline and after 8-weeks of intervention, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, carboxymethyllysine, TNF-α, hs-CRP and levels of serum glucose, lipid and insulin were assessed. AGEs restriction resulted in significant changes in mean differences levels of CML ( p < 0.004), FBG ( p < 0.01), HOMA-IR ( p < 0.04), TNF-α (p < 0.01) and MDA ( p < 0.02) in comparison to Reg-AGE. Moreover, weight ( p < 0.0001) and WC ( p < 0.001) significantly declined in the intervention group. Our results indicate that dAGEs restriction plus a low-calorie diet is superior to a low-calorie diet in amelioration of central obesity and IR at least partially through reduction of OS and inflammation in Mets subjects.