Open AccessMicro RNA-126 promoting angiogenesis in diabetic heart by VEGF/Spred-1/Raf-1 pathway: effects of high-intensity interval training
Author(s) -
Reza Sabzevari Rad,
Hossein Shirvani,
Hamideh Mahmoodzadeh Hosseini,
Alireza Shamsoddini,
Mohammad Samadi
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00610-4
Subject(s) - angiogenesis , high intensity interval training , diabetic cardiomyopathy , interval training , medicine , vascular endothelial growth factor , endocrinology , streptozotocin , diabetes mellitus , vascular endothelial growth factor a , vegf receptors , cardiomyopathy , heart failure
This study aims to investigate the effect of high-intensity interval training (HIIT) on gene expression of MicroRNA-126 ( miR-126 ) and serum concentration of vascular endothelial growth factor/ sprouty related EVH1 domain containing 1/ rapidly accelerated fibrosarcoma 1 (VEGF/Spred-1/Raf-1) proteins effective in cardiac tissue angiogenesis of diabetic rats.