Open AccessAqueous Cichorium intybus L. seed extract may protect against acute palmitate-induced impairment in cultured human umbilical vein endothelial cells by adjusting the Akt/eNOS pathway, ROS: NO ratio and ET-1 concentration
Author(s) -
Raziyeh Abdolahipour,
Azin Nowrouzi,
Masoumeh Khalili,
Alipasha Meysamie,
Samin Ardalani
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00603-3
Subject(s) - enos , umbilical vein , cichorium , protein kinase b , chemistry , medicine , microbiology and biotechnology , endocrinology , biology , biochemistry , apoptosis , in vitro , nitric oxide , botany , nitric oxide synthase
Endothelial dysfunction, which is a vascular response to oxidative stress and inflammation, involves a cascade of downstream events that lead to decreased synthesis of insulin-mediated vasodilator nitric oxide (NO) and increased production of vasoconstrictor protein endothelin-1 (ET-1). NO, and ET-1 production by endothelial cells is regulated by phosphatidylinositol 3-kinase (PI3K)-Akt-eNOS axis and mitogen-activated protein kinase (MAPK) axis of the insulin signaling pathway, respectively.