Open AccessTherapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus
Author(s) -
Fareha Wajid,
Raju Poolacherla,
Fatiha Kabir Mim,
Amna Bangash,
Ian H Rutkofsky
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00585-2
Subject(s) - melatonin , medicine , diabetes mellitus , oxidative stress , circadian rhythm , endocrinology
Diabetes mellitus is a complex metabolic disorder characterized by hyperglycemia occurring as a result of dysregulation and balance of various metabolic pathways. In recent years, circadian misalignment (due to altered sleep/wake, feeding/fasting cycles), has been intimately linked with the development of diabetes mellitus. Herein, we review our knowledge of oxidative stress, circadian rhythms control of metabolism, and the effects of its disruption on homeostasis while emphasizing the importance of melatonin, a nocturnally peaking, pineal hormone, as a potential therapeutic drug for the prevention and treatment of diabetes.