Open AccessGene ontology enrichment analysis of α-amylase inhibitors from Duranta repens in diabetes mellitus
Author(s) -
Pukar Khanal,
B. M. Patil
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00554-9
Subject(s) - in silico , amylase , enzyme , ic50 , biochemistry , in vitro , postprandial , signal transduction , biology , repens , pharmacology , chemistry , diabetes mellitus , gene , endocrinology , botany
Although α-amylase is the choice of target to manage postprandial hyperglycemia, inhibitors of this enzyme may get absorbed into the systemic circulation and modulate proteins involved in the pathogenesis of diabetes mellitus. Hence, the present study aimed to identify α-amylase inhibitors from Duranta repens via in silico and in vitro and predict their role in the modulation of multiple pathways involved in diabetes mellitus.