Open AccessThe Effects of Exercise Training on the Brain-Derived Neurotrophic Factor (BDNF) in the Patients with Type 2 Diabetes: A Systematic Review of the Randomized Controlled Trials
Author(s) -
Afsaneh Jamali,
Shahnaz Shahrbanian,
Seyed Morteza Tayebi
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00529-w
Subject(s) - cochrane library , brain derived neurotrophic factor , medicine , type 2 diabetes , randomized controlled trial , neurotrophic factors , animal studies , diabetes mellitus , medline , dementia , meta analysis , physical therapy , endocrinology , disease , receptor , political science , law
Glucose dysregulation is one of the distinctive features of type 2 diabetes that is associated with an increased risk of cognitive impairment and dementia. The low concentrations of brain-derived neurotrophic factor (BDNF) are reported in people with insulin resistance, metabolic syndrome, and type 2 diabetes. BDNF can be increased by an adjustment in lifestyle including caloric restriction and exercise training. Studies have reported controversial findings about physical activity and its association with BDNF, but there is no comprehensive conclusions on this issue. The aim of this study was to systematically review the effects of exercise training on BDNF levels in patients with type 2 diabetes.