Open AccessThe regulation of Niemann-Pick C1-Like 1 (NPC1L1) gene expression in opposite direction by Bacteroides spp. and related outer membrane vesicles in Caco-2 cell line
Author(s) -
Sara Ahmadi Badi,
Atiyyeh Motahhary,
Golnaz Bahramali,
Maryam Masoumi,
Seyedeh Fatemeh Sadati Khalili,
Nayereh Ebrahimzadeh,
Pegah Nouri,
Ayoub Rahimi,
Andrea Masotti,
Arfa Moshiri,
Seyed Davar Siadat
Publication year - 2020
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-020-00522-3
Subject(s) - bacteroides thetaiotaomicron , bacteroides fragilis , bacteroides , bacterial outer membrane , biology , microbiology and biotechnology , gene expression , abca1 , gene , bacteria , biochemistry , transporter , genetics , escherichia coli , antibiotics
The intestine has substantial role in cholesterol homeostasis due to the presence of various cholesterol transporters and gut microbiota. Bacteroides spp. are important members of gut microbiota that employ outer membrane vesicles (OMVs) to interact with host. In this regard, we evaluated the effect of Bacteroides fragilis, Bacteroides thetaiotaomicron and related OMVs on the gene expression of important cholesterol transporters, Niemann-Pick C1-Like 1 ( NPC1L1 ), ATP-binding cassette ( ABCA1 ), and liver X receptors ( LXR s) in Caco-2 cells.