Open AccessKCNQ1 common genetic variant and type 2 diabetes mellitus risk
Author(s) -
Taraneh Erfani,
Negar Sarhangi,
Mahdi Afshari,
Davood Abbasi,
Hamid Reza Aghaei Meybodi,
Mandana Hasanzad
Publication year - 2019
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-019-00473-4
Subject(s) - medicine , genotyping , type 2 diabetes mellitus , single nucleotide polymorphism , snp , genotype , genetics , sanger sequencing , allele , diabetes mellitus , bioinformatics , gene , endocrinology , biology , mutation
Type 2 diabetes mellitus (T2DM) is a multifactorial trait that both environmental and genetic factors contribute to its pathogenesis. The most common single nucleotide polymorphism (SNP) of the potassium voltage-gated channel subfamily Q member 1 (KCNQ1) gene, rs2237892, is highly associated with the risk of T2DM. The aim of the present study was to examine any association between KCNQ1 gene rs2237892 variant and risk of T2DM in a group of Iranian patients.