Open AccessIntegrated analysis of gene modulation profile identifies pathogenic factors and pathways in the liver of diabetic mice
Author(s) -
Trac D. Tran,
Yu-Chin Hsu,
Yu Chuen Huang,
ChaoJung Chen,
Wei Lin,
Ying Lin,
Wen Ling Liao,
Wei Yong Lin,
Jai Sing Yang,
Jinn Chyuan Sheu,
Shih Yin Chen,
Fuu Jen Tsai
Publication year - 2019
Publication title -
journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 33
ISSN - 2251-6581
DOI - 10.1007/s40200-019-00453-8
Subject(s) - modulation (music) , gene , computational biology , biology , microbiology and biotechnology , genetics , physics , acoustics
Type-2 diabetes mellitus (T2D) is a metabolic disorder that can progress to a serious chronic disease and frequently develops in obese individuals in association with various pathogenic complications that shorten the lifespan of these patients. The liver is an important organ regulating lipid metabolism, which is damaged in both obesity and T2D; however, the specific pathways involved in these pathogenic effects remain unclear. Establishing a suitable animal model that effectively mimics the human biological condition is a critical factor to allow for precise identification of T2D-related genes.